In mouse models it has been shown that both innate and adaptive immune cells exposed to specific gut microbes can infiltrate the tumour microenvironment and produce chemotactic factors like CXCL9, CXCR3, CCR9 and CXCL10, which induce trafficking of immune cells to the tumour site.53 58 Another hypothetical mechanism is cross-reactivity between microbial and tumour-associated antigens.59 Finally, the gut microbiome can produce metabolites, such as short-chain fatty acids, that can have systemic effects on host immunity.13 This evidence concerns the gene CXCL9 and neoplasm.