TARDBP and frontotemporal dementia: Many disease-associated mutations in TDP-43 have been identified in familial and sporadic ALS and occasionally in FTD, implicating TDP-43 dysfunction as central to disease (Benajiba et al., 2009; Borroni et al., 2009; Floris et al., 2015; Kabashi et al., 2008; Kovacs et al., 2009; Sreedharan et al., 2008; Synofzik et al., 2014; Van Deerlin et al., 2008).