TARDBP and amyotrophic lateral sclerosis: For example, mRNA levels for TDP-43 are upregulated in post-mortem tissue from patients with ALS/FTD as well as in a knock-in mouse model for the Q331K disease-causing mutation in TDP-43 (Gitcho et al., 2009; Mishra et al., 2007; White et al., 2018).