Located within the inactive TADs, five of the six aforementioned non-ATC loci (except EFCAB3) were highly methylated at shore regions of CpG island promoters (i.e., TBX2, TBX4, MRC2, and MARCH10) and non-CpG island promoter (i.e., NACA2) in 77 breast tumors compared to 10 normal controls (Fig. 4a, bottom; ref. # [37]). This evidence concerns the gene MRC2 and breast neoplasm.