To further survey 17q-related chromothriptic events, we defined a total of 170 dense ERα binding sites across the whole genome, with an average length of 2-Mb based on common ERα binding sites detected from MCF-7, T47D, and MDA-MB-134 breast cancer cell lines [30–32] (Fig. 3d and Additional file 2: Table S1). Here, ESR1 is linked to breast cancer.