ESR1 and breast cancer: Knowing that the 17q23 region is within one of the five regions that showed frequent inter−/intra-chromosomal rearrangements, we used nanopore sequencing for long-range genome mapping and independently confirmed frequent rearrangements of 18 junctions between ATC loci on 17q23 and an ERα hub on 20q13 in MCF-7 luminal breast cancer cells (Fig. 4d and Additional file 1: Figure S3).