In a stepwise multiple regression analysis, the effects of age, gender, body weight on admission, weight loss in last six months, changes in body weight during hospitalization, mobility, malnutrition, mid-thigh muscle mass area on admission, inflammation (CRP) and comorbidity (as independent variables) on absolute reduction of mid-thigh muscle mass area (as dependent variables) were tested (Table 4). This evidence concerns the gene CRP and nutritional deficiency disease.