We furthermore observed a drastic change in the transcription status of key genes related to testosterone synthesis such as P450scc, 3β-HSD and P45017α. Taken all together, these alterations explain well the reduction in sex hormones production, particularly testosterone, and decrease in sperm production, viability and motility that are the main causes of BF-induced infertility. The gene discussed is CYP11A1; the disease is Infertility.