In SH-SY5Y-APPswe neuroblastoma, TFEB induced an upregulation of several lysosomal and autophagic mRNAs (Figure 1B), but interestingly, it had strong effects on the expression of cathepsin mRNAs and particularly on that of CTSD encoding cathepsin D, one of the main proteases involved in C99 degradation. The gene discussed is CTSS; the disease is neuroblastoma.