The upstream regulators genes of candidate DcoExp modules, harboring functional candidate variants, were follows: DLG1 (Tan HF), AGER (Saddlebrown HF), SORT1 (Saddlebrown HF), HNRNPAB (Saddlebrown HF), TBX6 (Red HF), HSF1 (Purple HF and Darkgreen HF), LEPR (Lightgreen HF), DYSF (Lightgreen HF), BCKDK (Lightgreen HF), CHFR (Grey60 HF), ERN2 (Green HF), and RDH10 (Darkgreen HF). The gene discussed is TBX6; the disease is hydrops fetalis.