ARHGEF16 and hydrops fetalis: The top hub-genes from turquoise HF module, harboring fixed variants in HF or SF animals, and prioritized in the functional analysis, were ARHGEF16, IFT80, and PIGR. Rho Guanine nucleotide exchange factor 16 (ARHGEF16) codifies an ELMO1 interacting protein responsible to promote the clearance of apoptotic cells in a RhoG-dependent and Dock1-independent manner [66].