PIK3C2A and hydrops fetalis: The significant upstream regulators genes identified by the IPA core analysis associated with the turquoise HF module and harboring fixed functional candidate variants were PGR, EGFR, PIK3C2A, CUX1, TCHP, ETV5, KLF4, and ARID4A. The progesterone receptor (PGR) is crucial for the initiation of pregnancy and subsequent preservation of uterus health [81].