Penetrance of cardiolaminopathy indicators was nearly complete in the 7th decade of life with 98% of patients presenting with AVB, 100% with SVA, 90% with HF, 92% with serum biomarker hsTnT >14 ng/L, and 100% with NT-proBNP >125 pg/mL. This evidence concerns the gene NPPB and atrioventricular block.