IGHE and anaphylaxis: IgE-mediated reaction (type I) are characterized by quick onset of symptoms and signs (minutes to a few hours following intake) such as flushing, pruritus, rash, urticaria, throat tightness, shortness of breath, nausea, vomiting, cramping abdominal pain, diarrhea, hypotension and life-threatening anaphylaxis (cardiovascular collapse).