Strikingly, the restoration of neuronal mitophagy has been shown to promote the elimination of defective mitochondria, improve mitochondrial bioenergetics, and ameliorate cognitive decline in Caenorhabditis elegans models of AD and in the amyloid precursor protein/presenilin 1 APP/PS1 transgenic mouse AD model [154]. The gene discussed is PSEN1; the disease is Alzheimer disease.