TRPV1 and neuroblastoma: A few years later, PEA was proposed to activate TRPV1 in a somatic cell hybrid cell line composed of rat embryonic DRG neurons with a mouse neuroblastoma cell line (F11) since it was shown to increase intracellular Ca2+ concentrations in a dose-dependent fashion that was blunted if TRPV1 antagonists such as capsazepine and SB36679 were applied.