In accordance, HSF1 depletion in MCF-7 cells was shown to reduce the levels of HIF-1α and its target VEGF, which was at least partly dependent on HSF1’s ability to stimulate the expression of the mRNA-binding protein HuR that controls mRNA stability and translation of numerous proteins involved in cancer, including HIF-1α and VEGF [122]. Here, VEGFA is linked to cancer.