In Huh-7 and SMMC-7721 cells, HSF2 was shown to interact with euchromatic histone lysine methyl transferase 2 (EHMT2) in order to epigenetically silence the gene encoding fructose-bisphosphatase 1 (FBP1), which is a tumor suppressor and negative regulator of aerobic glycolysis [89] (Figure 3). This evidence concerns the gene HSF2 and neoplasm.