GPBAR1 and colonic neoplasm: However, many authors are interested in the effect of the secondary bile acid DCA, a proinflammatory and procarcinogenic natural chemical, on bile-acid-sensing receptors such as farnesoid X receptor (FXR) and G-protein-coupled bile acid receptor (TGR5) or gut microbiota study of DCA-induced dysbiosis [33,34,35], while the relevant role of the major bile acid CA in colon cancer progression is ignored.