In particular, multiple genetic alterations of RBPs with functions in splicing (e.g., Splicing factor 3b subunit 1 (SF3B1), U2 small nuclear RNA auxiliary factor 1 (U2AF1), serine and arginine rich splicing factor 2 (SRSF2)) have been described, especially in myeloid malignancies, and have been recently reviewed extensively [30,31,32,33,34,35], directing the focus of this review towards the wide range of RBPs regulating RNA beyond splicing. Here, SF3B1 is linked to myeloid neoplasm.