Indeed, a comprehensive study of metastases of 73 stage IV melanoma patients highlighted that four parameters are associated with better response to adoptive cell transfer (ACT) as immunotherapy, including a higher number of CD8+ T cells, a high M1/M2 macrophage ratio, the presence of Gal-9 expressing dendritic cells (DCs), and the increase of the Gal-3 expression by tumor cells. This evidence concerns the gene LGALS9 and neoplasm.