HAVCR2 and gastrointestinal stromal tumor: In human gastrointestinal stromal tumors (GISTs), infiltrated NK cells express TIM-3 in 6/8 (75%) of the GIST tissues, and all GIST tissues with TIM-3+ NK cell infiltration, were positive for Gal-9 expression by tumor cells [85], suggesting interactions between NK cells and tumor cells.