T2DM rats display higher NOX activity in leukocytes with increasing hyperglycemia (higher glycated hemoglobin (HbA1c) levels), which was associated with more pronounced mitochondrial oxidative stress (decreased aldehyde dehydrogenase 2 (ALDH-2) activity) and systemic inflammation as well as AGE/RAGE signaling (markers such as C-reactive protein (CRP) and methylglyoxal), all of which was normalized by glucosuria therapy (sodium/glucose cotransporter 2 (SGLT2) inhibition) [197]. Here, CRP is linked to Hyperglycemia.