NOS3 and diabetes mellitus: In accordance to our cross talk concept in the setting of diabetes, NADPH oxidases produce the “kindling radicals” leading to uncoupling of eNOS via the above described “redox switches” (e.g., BH4 depletion and S-glutathionylation) and may also contribute to direct dysfunction of eNOS by PKC-dependent phosphorylation of eNOS at Thr495 [55].