Cardiac NOX and serum XO activity are increased and NOX1/2 expression as well as eNOS uncoupling (measured by S-glutathionylation) are enhanced in T1DM rats (STZ model), which was partially normalized by treatment with an antioxidant organic nitrate (pentaerithrityl tetranitrate, PETN) via nuclear factor erythroid 2-related factor 2 (NRF2) activation [232]. Here, NOS3 is linked to type 1 diabetes mellitus.