In nasopharyngeal carcinoma (NPC), cancer cells promote M2 macrophage polarization via the release of TGF-β1 and IL-10, and the tumor-infiltrating M2 macrophages induce the recruitment of Treg cells by chemotaxis, resulting in the induction of the density of Treg cells in TME [25]. This evidence concerns the gene TGFB1 and neoplasm.