Inter-group comparison between healthy controls and patients with IBD and sporadic CRC identified ten proteins from the ultracentrifugation (i.e., AFM, A2M, C4BPA, C4B, C6, GSN, IGHM/MUCB, ITIH4, GC, HP) and seven proteins from the ExoQuickTM group (i.e., A2M, C4B, GSN, IGHA1, IGHA2, IGHM/MUCB, SERPINC1) to be differentially expressed (p < 0.05). This evidence concerns the gene IGHA2 and inflammatory bowel disease.