Conversely, the findings regarding the dominant effect of ACE I/D polymorphism on obesity are inconsistent as no significant association was found in the parallel studies conducted on a cluster of Asian (Korean adult women22,23 and children5,24), Chinese25,26, Japanese27, Caucasian21,28,29 and even African30 populations. Here, ACE is linked to obesity due to melanocortin 4 receptor deficiency.