CSF1R and Insulin resistance: To clarify the inflammatory contributions of macrophages in the progression to insulin resistance, we further took advantage of the modular nature of our RIDα/β mice and crossed them with our Csf1r promoter-driven rtTA mice to generate an inducible macrophage-specific RIDα/β-transgenic mouse model (hereafter referred to as RIDmac mice) (Figure 4A).