In human cancers, MYC and the transcription activator MIZ1 (MYC-interacting zinc-finger protein 1 [ZBTB17]) can form a protein complex that represses the expression of MIZ1 target genes, most notably cyclin-dependent kinase inhibitor genes such as CDKN1A (Conacci-Sorrell et al., 2014; Peukert et al., 1997; Wiese et al., 2013). Here, ZBTB17 is linked to cancer.