[12] In French Guiana, with an overall incidence of 1.5 per 100 person years and 10 per 100 person years for patients with cluster of differentiation lymphocytes 4 (CD4) counts less than 50 per mm3, disseminated histoplasmosis has been the first AIDS-defining illness and the first cause of death in French Guiana; [13,14] among hospitalized HIV-infected patients with advanced HIV, 42% had disseminated histoplasmosis, among those with CD4 counts less than 50 per mm3, 85% had histoplasmosis. The gene discussed is CD4; the disease is histoplasmosis.