However, although elevation of plasma Aβ42 levels to that of DIO mice in RC-fed and short-term HF-fed WT mice reproduced the decrease in plasma NOx, ET-1 levels were unaffected by Aβ42 per se and appear to be upregulated primarily by HF diet, with Aβ42 playing a permissive role. The gene discussed is EDN1; the disease is hydrops fetalis.