Oil red O staining of aortic arches from RC- or HF-fed (5 and 12 weeks of HF diet) WT and BACE1-KO mice and WT mice infused with Aβ42 or ScrP for 28 days (5 weeks of HF diet) exhibited no detectable lipid deposition (Supplemental Figure 5, A–D). Here, BACE1 is linked to hydrops fetalis.