Interestingly, ET-1 plasma levels were not altered in RC-fed WT mice infused with Aβ42 (versus ScrP controls), although short-term HF-fed mice given Aβ42 exhibited increased ET-1 compared with ScrP-infused controls (Figure 5E; diet × treatment, P < 0.05). Here, EDN1 is linked to hydrops fetalis.