BACE1 and hydrops fetalis: In addition, immunohistological analysis of perirenal aortic sections using isolectin B4 as a marker for endothelial cells and macrophages of RC- and HF-fed (12 weeks of HF diet) WT and BACE1-KO and WT mice infused with Aβ42 or ScrP for 28 days (5 weeks of HF diet) showed no macrophage infiltration or loss of endothelial cells (Supplemental Figure 6, A–C), with unchanged aortic wall thickness (Supplemental Figure 6D).