BACE1 and hydrops fetalis: Furthermore, RC-fed and short-term (5 weeks) HF-fed WT mice infused with Aβ42 (versus ScrP controls) also exhibited reduced NOx levels (Figure 5B; main effect of treatment, P < 0.01), whereas DIO mice given the BACE1 inhibitor M-3 displayed increased NOx levels (Figure 5C).