BACE1 protein expression was detectable in control (nonobese/diabetic) human temporal arteries (Figure 1C) and the expression of BACE1 mRNA in human internal mammary artery was higher in obese (body mass index [BMI] ≥ 35 kg/m2) compared with lean individuals (Figure 1D), although no difference in BACE1 mRNA expression was observed when correlated with insulin resistance or diabetes (Supplemental Figure 2 and Supplemental Table 1). Here, BACE1 is linked to diabetes mellitus.