Self-management of diabetes is critical for minimizing the risk of macrovascular and microvascular complications.1,2 However, self-managed glycemic control is often suboptimal, particularly for diabetic patients under intensive basal-bolus insulin regimens.3,4 Among others, many diabetic patients struggle in daily life to calculate and inject appropriate doses of basal and/or meal insulin, leading to episodes of hypo or hyperglycemia. This evidence concerns the gene INS and Hyperglycemia.