Switch in the expression of the PAR‐bZIP family members may relate to compromised xenobiotic metabolism associated with poor outcome in treated critically ill septic patients (Gachon et al, 2006; Woznica et al, 2018) while loss of PPARA may impede liver's ability to adapt its metabolic activities during sepsis (Paumelle et al, 2019). This evidence concerns the gene PPARA and Sepsis.