NR1I2 and Sepsis: Switch in the expression of the PAR‐bZIP family members may relate to compromised xenobiotic metabolism associated with poor outcome in treated critically ill septic patients (Gachon et al, 2006; Woznica et al, 2018) while loss of PPARA may impede liver's ability to adapt its metabolic activities during sepsis (Paumelle et al, 2019).