Several reports have suggested that the phosphorylation of FOXO3a by Akt at serine 253 (S253) resulted in its export into the cytosol and subsequent inactivation,33 whereas AMPK phosphorylates FOXO3a at serine 413 (S413), thereby leading to nuclear translocation and ultimately induces its target genes to regulate cancer cell death.34 The gene discussed is FOXO3; the disease is cancer.