We performed a statistical analysis of 19 potential risk factors for LAA thrombosis in NVAF patients and found that a total of 14 risk factors were statistically different between the thrombosis group and non‐thrombosis group (such as gender, age, complex‐LAA, AF course, NPAF, LAD, BNP, hypertension, diabetes, coronary heart disease, CHF, stroke/TIA/TE history, vascular disease, and high‐risk CHA2DS2‐VASc score), while the rate of effective anticoagulation, LVEDd, LVEF, and serum Fbg concentration were not statistically different between the two groups. The gene discussed is NPPB; the disease is diabetes mellitus.