Importantly, anti-phospholipid antibodies had in between entered the stage [21], and the false-positive syphilis serology definition was changed to a “positive finding of anti-phospholipid antibodies based on (1) an abnormal serum level of IgG or IgM anticardiolipin antibodies, (2) a positive test result for lupus anticoagulant using a standard method, or (3) a false-positive serologic test for syphilis known to be positive for at least 6 months and confirmed by Treponema pallidum immobilization or fluorescent treponemal antibody absorption test [6]. The gene discussed is CD40LG; the disease is syphilis.