CXCL8 and neoplasm: The functional roles of these genes have been demonstrated by genetic approaches32,34,38,59 and pharmacologic efficacy studies where the inhibition of integrin-β3 by cyclic peptide,60 TGF-β receptor type 1 by kinase inhibitor,61 and interleukin 8 by neutralizing antibody62 reduced tumor angiogenesis, tumor growth, and metastasis.