,20 GPR50 was reported to be associated with bipolar-affective disorder, lipid metabolism, thermogenesis, adipogenesis, and neuronal development.21, 22, 23, 24, 25 In our previous study, several GPCRs, including GPR50, were claimed to be involved in the reprogramming of somatic cells to cancer stem cells and in the maintenance of stemness function.26 The gene discussed is GPR50; the disease is bipolar disorder.