Using the Oncomine database (https://www.oncomine.org/resource/login.html) to examine the expression status of GPR50 in various cancers, we found dysregulated GPR50 expression (Wooster cell line dataset) that was especially enhanced in BRC, cervical (CEC), esophagus (ESC), liver (HCC), and lung (LUC) cancers (Figure 1A). This evidence concerns the gene GPR50 and hepatocellular carcinoma.