Notch signaling is involved in most multicellular processes in cancer cells, including cell fate, proliferation, metastasis, invasion, and stemness.53, 54, 55, 56, 57 Recent studies have depicted that the Notch signaling pathway can play either pro-oncogenic or tumor-suppressive roles in cancer cells.58, 59, 60 Notch signaling is normally triggered by a Notch-activating ligand that is subsequently processed through two proteolytic cleavage events via ADAM17 and the γ-secretase complex.48 This evidence concerns the gene ADAM17 and cancer.