The results of the present study revealed that urinary L-FABP secretion reflected decreases in muscle strength, muscle weight, and cross-sectional areas of muscle fibers, and the high levels of urinary L-FABP at 16 weeks were associated with a lower increasing rate of muscle strength in mature SDT fatty rats with hyperglycemia, hyperlipidemia, low levels of serum IGF-1, and kidney disease. The gene discussed is IGF1; the disease is hyperlipidemia.