The major findings of the current study were; 1) diabetes could reduce the expression of miR-133 in the cardiac muscle tissue, probably through a decrease in gene expression of Bcl-2 and an rise in gene expression of Bax, caspase 3 and caspase 8; 2) swimming increased the cardiac miR-133 expression probably through enhancement of Bcl-2 gene expression and anti-apoptotic proteins and decreased Bax, caspase 3 and caspase 8 proteins as apoptotic biomarkers in OVR.D.E animals. Here, CASP8 is linked to diabetes mellitus.