TNF and rheumatoid arthritis: Cyanobacteria and related phyla Nostocophycideae and Nostocales are enriched with ETN gathering andproduce secondary metabolites which have anti-inflammatory and immunosuppressant activities help RA patients [74,75].Anti TNF-α therapy has an advantageous impact on the microbiota synthesis [76].Later on, more studies and investigation are expected tounderstand whether P. copri serve arthritis contrasted with other intestine microscopic organisms [60].