TNF and obesity due to melanocortin 4 receptor deficiency: Obesity is characterised by accumulation of visceral fats [169], which is caused by many factors like diabetes, cardio-disease, hypertension,dyslipidemia, fatty liver and cancer, it is also caused by inflammatory molecules like TNF-α (Tumor Necrosis Factor Alfa) and Interleukins, which is observed to cause obesity[170][171].