Cag A upraise the accumulation of cytokinesresponsible for the inflammation like interferon-γ, IL-6, IL1, IL10, IL8, IL1β, TNFα and IL-7[87][90].It activates NF-κB, Wnt/β-catenin, PI3K/Akt, Ras, ERK/MAPK, sonic hedgehog and STAT3 is disorganized with the infection of H. Pylori CagA+ strains [89][88]. The gene discussed is IL1B; the disease is infection.