APOE and dementia: ROC curve analysis illustrated all-cause dementia prediction was significantly improved when adding the PRS (c-statistic: 0.792, p < 0.01), APOE (c-statistic: 0.787, p = 0.02) and the PRS & APOE (c-statistic: 0.792, p < 0.01) to age, sex, and education (c-statistic: 0.779).