The PRS was not predictive of MD diagnosis; however, APOE4+ was predictive of MD diagnosis (OR, 95% CI: 1.75, 1.00–3.07) and participants that were APOE ε4ε4 compared with APOE ε3ε3 participants had 15-fold increased risk of diagnosis (OR, 95% CI: 14.81, 5.12–42.87). The gene discussed is APOE; the disease is Menkes disease.