The tumours generated by increased YAP/TAZ activity in our nlsYAP5SA and LATS1/2 cKO mouse models are located in the periventricular region, similarly to ependymoma with YAP1-MAMLD1 fusion in humans, which consistently show a periventricular location, with or without an intraventricular component32, in contrast with RELA-fused ependymoma, which tend to occur more often in cortical-centred location64. This evidence concerns the gene WWTR1 and neoplasm.