Approximately 70% of supratentorial ependymomas are characterised by a fusion between C11ORF95 and RELA29,30, whereas ~4–10% carry the fusions of YAP1 with other genes encoding transcription factors: YAP1-MAMLD1, or YAP1-FAM118B29,31,32. Here, MAMLD1 is linked to ependymoma.