However, we observed that LATS1/2 cKO animals depleted of both copies of YAP1 exhibit a significant reduction (p < 0.001, Dunn’s multiple comparisons test) in average tumour size compared with LATS1/2 cKO animals (Fig. 4b), indicating that level of YAP expression impacts tumour size. Here, LATS1 is linked to neoplasm.