Last, YTHDF2 is upregulated in pancreatic cancer and has two roles in cancer development: 1) YTHDF2 promotes cell proliferation, since it was observed that knocking down YTHDF2 results in the activation of the AKT/GSK3β/Cyclin D1 pathway, leading to G1 arrest, and 2) the YTHDF2-mediated decay of yes-associated protein (YAP) may influence the epithelial–mesenchymal transition, since overexpression of YAP results in decreased expression of epithelial markers and increases in mesenchymal markers98. The gene discussed is YTHDF2; the disease is cancer.