METTL3 and glioblastoma: Reduction of m6A modification by the depletion of METTL3 or METTL14 or the chemical inhibition of FTO upregulates the mRNA expression of critical oncogenes such as ADAM19, EPHA3, and KLF4 and downregulates the mRNA expression of many tumor suppressors, including CDKN2A, BRCA2, and TP53I11 mRNAs, resulting in overall enhanced GBM stem cell growth, self-renewal, and tumorigenesis91.