Last, YTHDF2 is upregulated in pancreatic cancer and has two roles in cancer development: 1) YTHDF2 promotes cell proliferation, since it was observed that knocking down YTHDF2 results in the activation of the AKT/GSK3β/Cyclin D1 pathway, leading to G1 arrest, and 2) the YTHDF2-mediated decay of yes-associated protein (YAP) may influence the epithelial–mesenchymal transition, since overexpression of YAP results in decreased expression of epithelial markers and increases in mesenchymal markers98. This evidence concerns the gene YTHDF2 and familial pancreatic carcinoma.