Overexpressed HDGF protein can be secreted and promotes tumor angiogenesis, while nuclear HDGF stimulates the expression of glucose transporter type 4 (GLUT-4) and enolase 2 (ENO2) mRNAs, resulting in increased levels of glycolysis and subsequently causing tumor growth and liver metastasis84. This evidence concerns the gene SLC2A4 and neoplasm.