Correspondingly, IPA pointed in RA-ST to TCR-, complement-, TNF-, IFN-, and IL6-receptor mediated signalling as well as chemotactic and inflammatory processes related to CXCL9, CXCL10, CXCL11, CXCL13, IL15, IL32, and CCL13 (supplementary figures 2-3). Here, TNF is linked to rheumatoid arthritis.