This revealed that the top 100 RA-ST genes were best represented by those induced in M1 macrophages (generated by LPS and IFNγ stimulation) with scores up to 96% of RA-ST score, and in monocytes stimulated with S. aureus, C. pneumoniae, LPS or A. fumigatus, which reached up to 76%, 76%, 73% and 59% of RA-ST scores, respectively (supplementary table 7, worksheet-A). This evidence concerns the gene IFNG and rheumatoid arthritis.