In total, 38 reference transcriptomes of 12 cell types were selected from own resources and from the GEO database, including synovial fibroblasts, endothelial cells, platelets, CD19+B-, CD4+T-, CD8+T-, CD56+NK-cells, CD1c+DC, CD14+ monocytes (Mo), macrophages (Mf), Mf from RA synovial fluid (RA-SF) and CD15+ granulocytes (supplementary table 4)25–31. The gene discussed is CD4; the disease is rheumatoid arthritis.