In RA-ST, myeloid activation patterns overlapped with response pattern induced by bacterial pathogens or components like LPS, M1-Mf, M. tuberculosis, S. aureus, L. rhamnosus, NOD2-ligand (muramyl dipeptide), TLR2/1-ligand (triacylated lipopeptide), F. tularensis subsp. The gene discussed is NOD2; the disease is rheumatoid arthritis.