Our findings are consistent with those of Rempe et al. [16], who reported that MMP2 and MMP9 activities are elevated in a TLE rat model, and with those of Korotkov et al. [18], who observed increased MMP3 expression in the hippocampus of TLE-HS patients and in the rat TLE model. This evidence concerns the gene MMP3 and histiocytic sarcoma.