TRPV1 and neuropathy: These data contrast sharply with the aforementioned clinical data, as well as with multiple preclinical studies implicating TRPV1 and TRPV1+ afferents in mechanical hyperalgesia following neuropathy (Pomonis et al., 2003; Rashid et al., 2003; Kanai et al., 2005; Christoph et al., 2007; Watabiki et al., 2011).