BRCA1 and ovarian cancer: Next, we performed a targeted association analysis of two well-known genes associated with ovarian cancer and chemotherapeutic outcomes: BRCA1 and BRCA2. Of the 238 SNPs in BRCA1 and 256 in BRCA2, we identified 56 independent variants in BRCA1 and 86 such variants in BRCA2 after pruning for LD (r2 > 0.8).