During a totally laparoscopic surgery for colon cancer, we used IGFI to evaluate the bowel perfusion only under laparoscopy, and the mean operation time is 125.8 ± 34.9 min, which is significantly shorter than the control group, and we attributed this difference to the fast and accurate judgment of bowel perfusion and the simplicity of this procedure. The gene discussed is IGF1; the disease is colonic neoplasm.