ELN and neoplasm: The most effective enzyme mix comprised collagenase XI, DNAse I and dispase II with efficient proteolytic activity towards interstromal cell connections, collagen type I and hyaluronidase V to hydrolyze glycosidic linkages in hyaluronic acid and elastase to address elastin fibers which are associated with lysyl oxidase-like 2 mediated tumor migration [27–31].