Hypoxemia results in an increase in cerebral blood flow, increase in vascular permeability through a higher oxidative stress or low-grade inflammation or increased expression of vascular endothelial growth factor (VEGF), venous outflow restriction, free radicals induced pump failure, lipid peroxidation, and destabilization of astrocyte membrane causing astrocyte swelling and hence causes cerebral edema [1, 23–25]. Here, VEGFA is linked to Hypoxemia.