Five predictors were selected in a final model: preimplantation NT-proBNP > 1745 pg/mL (hazard ratio (HR) 2.47, 95% confidence interval (CI) 1.35–4.49, P = 0.0031), moderate/severe TR (HR 1.50, 95% CI 0.82–2.73, P = 0.1857), TSH > 4 mIU/L (HR 1.47, 95% CI 0.79–2.73, P = 0.2204), previous pulmonary hypertension (HR 1.84, 95% CI 0.98–3.48, P = 0.0595) and history of syncope (HR 0.64, 95% CI 0.32–1.27, P = 0.1993). This evidence concerns the gene NPPB and pulmonary arterial hypertension.