As described in a retrospective cohort of 160 advanced GC patients who underwent potentially curative surgery with or without chemotherapy, phosphorylated AKT positive patients had a good prognosis in terms of OS and relapse-free survival, suggesting that pAKT may be a biomarker for better outcomes for GC patients undergoing gastrectomy regardless of the PIK3CA mutation status [14]. This evidence concerns the gene AKT1 and gastric cancer.