To confirm whether HHV-6 reactivation occurs in the patients with epilepsy, the detection of HHV-6 U89/90 gene expression in PBMC, HHV-6 load in WPB DNA, and the presence of HHV-6 encoded early (p41) and late virion envelope glycoproteins gH (gp100) and gB (gp116) expression in PBMC was done. Here, PMEL is linked to epilepsy.