The levels of ACIVAbs IgM (0.18 ± 0.02 vs. 0.12 ± 0.01; p = 0.016) and CIV-DP (1.16 ± 0.05 vs. 0.74 ± 0.03; p < 0.001) in patients with T2D were significantly lower than in controls (Figure 3A,B). Here, CD40LG is linked to type 2 diabetes mellitus.