In the diabetic population the advanced glycation end products (AGEs), endothelin-1 (ET-1), matrix metalloproteinases (MMPs), high-sensitivity C-reactive protein (hsCRP), N-terminal fragment of brain natriuretic peptide (NT-proBNP), high-sensitivity troponin T (hsTnT), lipids, and albuminuria can be useful in predicting of cardiovascular disease [13,14]. The gene discussed is EDN1; the disease is cardiovascular disorder.