When we compared the serum levels of AEAbs IgM, AEAbs IgG, and AEAbs IgA in T2D patients with those of non-diabetic subjects, we observed significant increases in AEAbs IgA (Figure 2A), whereas the levels of AEAbs IgM and AEAbs IgG were decreased (Figure 2C,D). The gene discussed is CD40LG; the disease is type 2 diabetes mellitus.