The survival fractions of MCL-treated H460 were slightly lower than the control cells after exposure to the same dose IR (2–6 Gy) under both normoxia and hypoxia, and SERDq (Table 3) showed an increase to 1.07 under normoxia and 1.21 under hypoxia in H460 cells, markedly lower than those of p53-null H1299 and Calu-1 cells, as shown in Figure 5A and B. Consistently, no significant decrease in HIF-1α protein level was observed after MCL treatment in H460 cells (Figure 5C). Here, TP53 is linked to mantle cell lymphoma.