In our analysis, NEDD4 expression (but not NEDD4L) is conspicuous, initially for being differentially correlated with AXIN2 expression, negatively in normal tissue and positively in cancer tissue; and additionally, for being positively correlated with TCF7L1 in normal tissue, which is opposite to AXIN2, but being positively correlated with TCF7 expression in tumor tissue, as AXIN2. These findings are consistent with the suggested role of NEDD4 as a tumor suppressor in colorectal cancer. This evidence concerns the gene NEDD4 and cancer.