LEF1 and neoplasm: However, since TCF7/LEF1 expression is generally low in the control samples from normal tissue (Figure 1), it is likely that the few cells expressing any TCF7 and LEF1 in these isolated normal tissue samples belong to the immune system, and any differences in amount of TCF7/LEF1 transcripts in these samples may reflect varying amounts of immune tissue included in these samples, which would be correlated to immune system-typical transcripts, rather than suggesting a switch in target genes regulated by TCF7/LEF1 in normal and tumor tissue.