Here, we aimed to assess whether predictions about Wnt signaling in colorectal cancer from tissue-culture and animal model systems could be confirmed by a meta-analysis of compatible transcriptomics studies of paired normal and tumor biopsy samples from human patient, and whether specific LEF/TCF gene-correlated transcriptomes imply LEF/TCF gene-specific function in normal or tumor tissue. This evidence concerns the gene HNF4A and colorectal cancer.