While in tumor tissue TCF7L1, and even more so LEF1 gene expression is correlated with transcripts associated with the extracellular matrix (ECM); and expression of AXIN2 with TCF7 is correlated with regulation of Wnt signaling (particularly Wnt receptor catabolic processes), with this correlation being stronger in tumor than normal tissue. The gene discussed is LEF1; the disease is neoplasm.