FZD5 and colorectal cancer: Furthermore, there is a correlation with the expression of genes such as RNF43 and ZNRF3, which function as Membrane E3 ligases to promote ubiquitination and degradation of Wnt receptor proteins, including FZD receptor proteins [56], and suggestively, RNF43 and ZNRF3 are frequently found mutated in colorectal cancer [57,58].