We chose to monitor additionally the expression of AXIN2, DKK1, FZD7, and LGR5. AXIN2 is a direct Wnt target gene [33,34] used here as a reliable indicator of intracellular Wnt/β-catenin pathway activity, and because increased expression has been reported in colorectal tumor tissue [35]. The gene discussed is LGR5; the disease is colorectal neoplasm.