TCF7L1 and neoplasm: Even more remarkably, this correlation is absent or much reduced in tumor tissue, and in the one study that has relevant information on kRAS mutant status in samples [27], it suggests that this correlation between TCF7L1 and FZD7 is particularly strong in KRAS-mutant normal tissue (Figure 2C), and is strongly reduced in KRAS mutant tumor (Figure 2D).