iPSC-derived motor neurons from ALS patients bearing a TARDBP mutation (G298S) present an increase in the mRNA for two isoforms of the enzyme phosphofructokinase-1 (PFK1), PFKM, and PFKP, which are considered to be rate limiting and control the rate of glycolysis [107]. The gene discussed is TARDBP; the disease is amyotrophic lateral sclerosis.